Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes
In: Journal of Medical Genetics, Jg. 59 (2021-02-01), S. 220-229
Online
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Zugriff:
BackgroundIdentifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming.MethodsThe Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer.ResultsOncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms.ConclusionThe MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.
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Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes
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Autor/in / Beteiligte Person: | Omar, Jamil ; Mohamad Nasir Shafiee ; Thong, Meow-Keong ; Daren C Y Teoh ; Zatul Akmar Ahmad ; Chun Sen Lim ; Lim, Joanna ; Cheah, Nellie ; George, Angela ; Joseph K Joseph ; Yeung Sing Chin ; Teo, Soo-Hwang ; Doris S Y Chow ; Badrul Zaman Abdullah ; Bleiker, Eveline M. A. ; Boom Ping Khoo ; Tayib, Shahila ; Teck Sin Tan ; Subramaniam, Suguna ; Chee Kin Fong ; Matin Mellor Abdullah ; Soo Fan Ang ; Yoke Ching Foo ; Low, John ; Raman, Rakesh ; Yin Ling Woo ; Kwong Sheng Loo ; Siu Wan Wong ; Ahmad Muzamir Ahmad Mustafa ; Keng Joo Lim Lim ; Yoon, Sook-Yee ; Nor Huda Mat Ali ; Kean Fatt Ho ; Rethanavelu, Kavitha ; Pei Jye Voon ; Nur Tiara Hassan ; Ahmad, Syuhada ; Aliyas, Ismail ; Beng Hock Teh ; Mohd Pazudin Ismail ; Padmanabhan, Heamanthaa ; Muin, Ileena ; Ismail, Ghazali ; Mastura Md Yusof ; Chee Meng Yong ; Haniffa, Muzhirah ; Deniel, Azura ; Makanjang, Mary ; Mohamad Faiz Mohamed Jamli ; Rozita Abdul Malik ; Noor Azmi Mat Adenan ; Eunice S E Ong ; Tho, Lye-Mun ; Suberamaniam, Anuradha ; Lip Hen Moey ; Chui Ling Lee ; Ismail, Fuad ; Winnie Peitee Ong ; Ramasamy, Vickneswaren ; Raja, Arivendran ; Shao Yan Lau ; Saw Joo Lee ; Zarina Abdul Latiff ; Boon Kiong Lim ; Kumarasamy, Suresh ; Wee Teik Keng ; Kin Wah Leong ; Wee Wee Sim ; Swee Kiong Kho ; Gwo Fuang Ho ; Azura Rozila Ahmad ; Paul Hock Oon Ng ; Mohd Norazam Mohd Abas ; Mohd Rushdan Md Noor ; A. B.Ahmad Radzi ; Mariapun, Shivaani ; Ch'ng, Gaik-Siew ; Michael C K Lim |
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Zeitschrift: | Journal of Medical Genetics, Jg. 59 (2021-02-01), S. 220-229 |
Veröffentlichung: | BMJ, 2021 |
Medientyp: | unknown |
ISSN: | 1468-6244 (print) ; 0022-2593 (print) |
DOI: | 10.1136/jmedgenet-2020-107416 |
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