Effect of lithium on hepatic lipid peroxidation and antioxidative enzymes under different dietary protein regimens
In: Journal of Applied Toxicology, Jg. 18 (1998-05-01), S. 187-190
Online
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Zugriff:
Lithium in the form of lithium carbonate was administered at a dose level of 1.1 g kg(-1) food to rats fed normal (18% protein), low-protein (LP; 8%) and high-protein (HP; 30%) diets for a period of 1 month. A highly significant (53%) increase in the level of lipid peroxidation (LPO) was observed in protein-deficient rats but this increase was marginal in rats fed an HP diet (18%). Lithium treatment of rats fed a normal diet caused a marked decrease (22%) in LPO. Lithium administration to rats fed an LP diet also reduced the raised levels of LPO to the extent of 16%. Furthermore, lithium treatment normalized the HP-induced increase in the levels of LPO. The activities of glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) were reduced significantly in protein-deficient rats. On the other hand, an HP diet caused a decrease in SOD activity only. The activities of GPx and catalase were appreciably enhanced in lithium-treated rats. Lithium treatment to LP-fed rat markedly increased GPx activity and brought the decreased levels of SOD and catalase to within normal limits. Lithium administration to HP-fed rats did not cause any significant alteration in the activities of these antioxidative enzymes.
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Effect of lithium on hepatic lipid peroxidation and antioxidative enzymes under different dietary protein regimens
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Autor/in / Beteiligte Person: | Tandon, Aparna ; Dhawan, Devinder K. ; Nagpaul, J. P. |
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Zeitschrift: | Journal of Applied Toxicology, Jg. 18 (1998-05-01), S. 187-190 |
Veröffentlichung: | Wiley, 1998 |
Medientyp: | unknown |
ISSN: | 1099-1263 (print) ; 0260-437X (print) |
DOI: | 10.1002/(sici)1099-1263(199805/06)18:3<187::aid-jat495>3.0.co;2-y |
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