1419-P: Lower Medium and Total HDL Particle Concentrations May Contribute to CVD Risk in Type 1 Diabetes
In: Diabetes, Jg. 69 (2020-06-01)
Online
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Zugriff:
Although it has long been proposed that HDL is dysfunctional in type 1 diabetes (T1D), this hypothesis has not been formally tested in large cohorts using validated functional and biochemical HDL metrics. We therefore determined whether HDL particle concentration (HDL-P) and function differed between 187 middle-aged adults with childhood-onset T1D (mean age 51 years, T1D duration 43 years, 53% women) and 200 individuals with normal glucose tolerance (NGT) of similar age and sex distribution. HDL-P was assessed by calibrated ion mobility analysis. HDL function, i.e., serum HDL cholesterol efflux capacity, was quantified in J774 cells using a validated assay. Separate stepwise linear regression models were constructed for each HDL metric, allowing for T1D status and potential confounding factors, including HDL cholesterol (HDL-C). The presence of significant effect modification by sex was evaluated. After adjustment, the concentrations of total (T-HDL-P; β=-0.44, p=0.09) and medium-sized (M-HDL-P; β=-0.84, p In conclusion, lower levels of T-HDL-P and M-HDL-P in T1D may explain in part the higher cardiovascular risk in T1D, as these metrics were recently shown to be associated with protection from vascular complications. The lack of a difference in M-HDL-P by sex in T1D may contribute to the loss of cardioprotection associated with female sex. Disclosure T. Costacou: None. T. Vaisar: Consultant; Self; AstraZeneca. J. Ju: None. K. Bornfeldt: None. T.J. Orchard: None. J. Heinecke: None. Funding National Institutes of Health (HL130153, DK34818)
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1419-P: Lower Medium and Total HDL Particle Concentrations May Contribute to CVD Risk in Type 1 Diabetes
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Autor/in / Beteiligte Person: | Costacou, Tina ; Orchard, Trevor J. ; Ju, Jinghui ; Vaisar, Tomas ; Heinecke, Jay W. ; Bornfeldt, Karin E. |
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Zeitschrift: | Diabetes, Jg. 69 (2020-06-01) |
Veröffentlichung: | American Diabetes Association, 2020 |
Medientyp: | unknown |
ISSN: | 1939-327X (print) ; 0012-1797 (print) |
DOI: | 10.2337/db20-1419-p |
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