Blood Coagulability in Chronic Renal Failure

The blood coagulability of 28 chronic non-hemodialysed renal failure patients was investigated. Systemic diseases such as systemic lupus erythematosus or diabetes mellitus were excluded because of their own coagulation abnormalities. All patients were in uremic state. Fasting blood samples were drawn from antecubital vein early in the morning with 3.8% sodium citrate as the anticoagulant. When not measured immediately, samples were stored at -80°C. Following assessments were performed: PT, APTT, TEG (whole blood method), fibrinogen, factor II, V, VII, VIII, IX, X, XI, XII procoagulant activities, factor VIII related antigen (Laurell's method) (VIIIANG), antigen levels of antithrombin III ATIII), and α2 macrogloburin (α2MG) with Mancini's method, serial dilution protamin sulfate test (SDPS), ethanol gelation test (EG), high molecular weight fibrinogen complex (HMWFC) (gel filtration method), fibrin/fibrinogen degradation products (latex aggregation method) (FDP). BUN, creatinine, blood pH, total CO2 and hematocrit were also determined as the indicators of uremic state. Results were as follows. Shortened results were obtained in APTT (p