Effect of mometasone furoate nasal spray (MFNS) on nasal polyposis*1
In: Journal of Allergy and Clinical Immunology, Jg. 113 (2004-02-01), S. S282
Online
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Zugriff:
Rationale Oral glucocorticosteroids have beneficial effects in nasal polyposis. Effects with nasal corticosteroids have been inconsistent. Two randomized, double-blind, parallel group, multicenter (n=354, 310), 4-month studies were conducted to compare MFNS 200 μg BID, 200 μg QD and placebo. Methods Nasal congestion/obstruction, rhinorrhea, postnasal drip, loss of smell scores and peak nasal inspiratory flow (PNIF) were recorded daily. Adults with bilateral polyposis and AM nasal congestion at least moderate during placebo run-in were enrolled. Polyp size was graded by nasal endoscopy. Primary endpoints were changes in polyp size score at endpoint and congestion score over month1. Results Study #1: Polyp size decreased with MFNS 200 mg BID (27%, p=0.011) and MFNS 200 mg QD (33%, p Conclusions MFNS 200 μg BID has demonstrated activity in the treatment of nasal polyposis.
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Effect of mometasone furoate nasal spray (MFNS) on nasal polyposis*1
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Autor/in / Beteiligte Person: | Bloom, M. ; Staudinger, Heribert |
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Zeitschrift: | Journal of Allergy and Clinical Immunology, Jg. 113 (2004-02-01), S. S282 |
Veröffentlichung: | Elsevier BV, 2004 |
Medientyp: | unknown |
ISSN: | 0091-6749 (print) |
DOI: | 10.1016/j.jaci.2004.01.492 |
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