Thiopurine Treatment in Childhood Leukemia
In: Advances in Experimental Medicine and Biology ISBN: 9781461374565; (1998)
Online
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Zugriff:
The thiopurine antimetabolites 6-mercaptopurine (6MP) and 6-thioguanine (TG) are important chemotherapeutic drugs in the treatment of acute lymphobastic leukemia. Both drugs are initially converted by the purine enzyme hypoxanthine guanine phos-phoribosyl transferase (HGPRT) into 6-thio-inosine monophoshate (TIMP) and 6-thio-guanosine monophosphate (TGMP), respectively. Further conversion of TIMP to TGMP via 6-thio-xanthine monophosphate (TXMP) is catalyzed by two enzymes, IMP-dehydro-genase (IMPDH) and GMP-synthetase, respectively. IMPDH is the rate-limiting enzyme in these two enzymatic steps (1). Subsequently, TGMP is converted by consecutive steps to the 6-thio-guanosine triphosphates: 6-thio-GTP (TGTP) and 6-thio-deoxy-GTP (TdGTP), which are incorporated into RNA and DNA, respectively.
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Thiopurine Treatment in Childhood Leukemia
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| Autor/in / Beteiligte Person: | Keuzenkamp-Jansen, C.W. ; Jos P.M. Bökkerink ; R.A. de Abreu ; Trijbels, J. F. M. ; Stet, E. H. |
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| Quelle: | Advances in Experimental Medicine and Biology ISBN: 9781461374565; (1998) |
| Veröffentlichung: | Springer US, 1998 |
| Medientyp: | unknown |
| ISBN: | 978-1-4613-7456-5 (print) |
| DOI: | 10.1007/978-1-4615-5381-6_133 |
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