Short Communication: HTLV-I/HTLV-II Coinfection in an AIDS Patient from São Paulo, Brazil
In: AIDS Research and Human Retroviruses, Jg. 16 (2000-05-01), S. 715-719
Online
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Zugriff:
A serological survey for HTLV infection identified an AIDS patient with HTLV-I/HTLV-II dual seroreactivity. Two further sequential blood samples were collected (samples A and B) for PCR, restriction fragment length polymorphism (RFLP), and sequence analyses of HTLV-I and HTLV-II strains. PCR analyses confirmed dual infection in both samples. Restriction digests of the env region amplified from sample A showed the presence of an HTLV-IIa subtype; the HTLV-II provirus was found to be defective in the pol and env regions in the second sample from this patient. RFLP analysis of the HTLV-II LTR region of both samples confirmed this finding and identified an a5/bzl restriction type. Nucleotide sequence analyses revealed full homology in the HTLV-I env and LTR regions and in the HTLV-II LTR region between the two samples. These findings document the first case of an HTLV-I/HTLV-II coinfection that was fully confirmed and characterized by means of molecular analyses.
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Short Communication: HTLV-I/HTLV-II Coinfection in an AIDS Patient from São Paulo, Brazil
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Autor/in / Beteiligte Person: | Chieco-Bianchi, Luigi ; Maria Luisa Calabrò ; Caterino-de-Araujo, Adele ; Favero, Anna ; Suleiman, Jamal ; Elizabeth de los Santos-Fortuna |
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Zeitschrift: | AIDS Research and Human Retroviruses, Jg. 16 (2000-05-01), S. 715-719 |
Veröffentlichung: | Mary Ann Liebert Inc, 2000 |
Medientyp: | unknown |
ISSN: | 1931-8405 (print) ; 0889-2229 (print) |
DOI: | 10.1089/088922200308710 |
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