Parathion Toxicokinetics in Resistant and Susceptible Strains of the Greenbug (Homoptera: Aphididae)
In: Journal of Economic Entomology, Jg. 86 (1993-10-01), S. 1317-1323
Online
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Zugriff:
Results of studies to determine the mechanism of resistance in a parathion resistant strain of green bugs, Schizaphis graminum (Rondani), indicated that the resistance mechanism is a combination of metabolic detoxification and target site insensitivity. In vivo metabolism experiments confirmed involvement of metabolic detoxification based on decreased rates of paraoxon formation in the resistant strain. Reduced paraoxon formation is either the result of lower activity of cytochrome P450-dependent oxidases that catalyze desulfuration of parathion, or increased hydrolytic metabolism of paraoxon. Resistance was also associated with a 2.5-fold decrease in sensitivity of acetylcholinesterase to paraoxon inhibition; therefore, we conclude that target site insensitivity and metabolic detoxification interact to confer overall resistance levels.
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Parathion Toxicokinetics in Resistant and Susceptible Strains of the Greenbug (Homoptera: Aphididae)
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Autor/in / Beteiligte Person: | Siegfried, Blair D. ; Ono, Midori |
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Zeitschrift: | Journal of Economic Entomology, Jg. 86 (1993-10-01), S. 1317-1323 |
Veröffentlichung: | Oxford University Press (OUP), 1993 |
Medientyp: | unknown |
ISSN: | 1938-291X (print) ; 0022-0493 (print) |
DOI: | 10.1093/jee/86.5.1317 |
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