Nickel-Catalyzed N-Arylation of Amides with (Hetero)aryl Electrophiles by Using a DBU/NaTFA Dual-Base System
In: Synlett, Jg. 32 (2020-12-15), S. 1665-1669
Online
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Zugriff:
The first nickel-catalyzed N-arylation of amides with (hetero)aryl (pseudo)halides employing an organic amine base is described. By using a bis(cyclooctadienyl)nickel/8-[2-(dicyclohexylphosphinyl)phenyl]-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphaadamantane catalyst mixture in combination with DBU/NaTFA as a dual-base system, a diversity of (hetero)aryl chloride, bromide, tosylate, and mesylate electrophiles were successfully cross-coupled with structurally diverse primary amides, as well as a selection of secondary amide, lactam, and oxazolidone nucleophiles.
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Nickel-Catalyzed N-Arylation of Amides with (Hetero)aryl Electrophiles by Using a DBU/NaTFA Dual-Base System
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Autor/in / Beteiligte Person: | Stradiotto, Mark ; Lundrigan, Travis ; Tassone, Joseph P. |
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Zeitschrift: | Synlett, Jg. 32 (2020-12-15), S. 1665-1669 |
Veröffentlichung: | Georg Thieme Verlag KG, 2020 |
Medientyp: | unknown |
ISSN: | 1437-2096 (print) ; 0936-5214 (print) |
DOI: | 10.1055/a-1337-6459 |
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