Light-Enhanced Bacterial Killing and Less Toxic Cell Imaging: Multicationic Aggregation-Induced Emission Matters
In: ACS Sustainable Chemistry & Engineering, Jg. 6 (2018-09-14), S. 15064-15071
Online
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Zugriff:
The newly emerged pathogenic bacteria leads to the bactericides generations one by one, which is definitely a long-term and costly process. For the small organic molecule used as antibacterial materials, photostability, biomembrane penetrating ability, and long-term antibacterial ability still are questionable. In this work, we synthesized the multiple-cation-charged aggregation-induced emission (AIE)-active polymer 1,2-diphenyl-1,2-bis(4-(pyridin-4-yl)phenyl) ethane–1,8-dibromooctane (DBPE-DBO). Due to the incorporating the dark toxicity from positively charged polymers, and the phototoxicity from generation of singlet oxygen, as well as AIE-active fluorescence performance, DBPE-DBO could be employed as an efficient bacteria targeting, imaging, and killing materials. Interestingly, DBPE-DBO was less toxic to the normal mammalian cells, which leads us to verify that DBPE-DBO could be used as a very cell-membrane permeable nucleus imaging probes. Thus, our research results may provide a new concept for the...
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Light-Enhanced Bacterial Killing and Less Toxic Cell Imaging: Multicationic Aggregation-Induced Emission Matters
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Autor/in / Beteiligte Person: | Lei, Ziqiang ; Yin, Weidong ; Qin, Yanfang ; Lei, Lei ; Ma, Yucheng ; Ma, Hengchang ; Wang, Tao ; Zhang, Shaoxiong ; Yang, Yuan ; Yang, Manyi ; Yin, Pei |
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Zeitschrift: | ACS Sustainable Chemistry & Engineering, Jg. 6 (2018-09-14), S. 15064-15071 |
Veröffentlichung: | American Chemical Society (ACS), 2018 |
Medientyp: | unknown |
ISSN: | 2168-0485 (print) |
DOI: | 10.1021/acssuschemeng.8b03540 |
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