Protection of SNpc neurons by water soluble CoQ 10 in a paraquat induced rat model of Parkinson's disease: The role of neurotrophic factors
In: The FASEB Journal, Jg. 24 (2010-04-01)
Online
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Zugriff:
Parkinson’s disease (PD) is a common neurodegenerative disorder that results from the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Studies show that mitochondrial dysfunction/oxidative stress is a major contributor to this disease. Currently there is no treatment to halt the progression of PD. Recently we have shown that water-soluble coenzyme Q10 (WS-CoQ10, NRC technology licensed to Zymes LLC) prevents the loss of dopaminergic neurons in the SNpc and ameliorates the symptoms of paraquat (PQ)-inducted PD in the rat model. We have observed that there is activation of astroglia in the brains of WS-CoQ10 treated animals. Whether this activation plays a role in protecting SNpc neurons is unknown. It is possible that activated astroglia cells produce neurotrophic factors that may protect neurons under oxidative stress. We analyzed brain tissue samples from PQ treated PD rats fed with either placebo or WS-CoQ10 for DA neurons, activation of astroglia and levels of...
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Protection of SNpc neurons by water soluble CoQ 10 in a paraquat induced rat model of Parkinson's disease: The role of neurotrophic factors
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Autor/in / Beteiligte Person: | Sikorska, Marianna ; Pandey, Siyaram ; Rafo, N. ; Somayajulu-Nitu, Mallika ; Facecchia, Katie ; Borowy-Borowski, Henryk ; Cohen, Jerome S. ; Dadwal, P. ; Church, K. ; Shelley B Weinstock ; Sandhu, Jagdeep K. |
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Zeitschrift: | The FASEB Journal, Jg. 24 (2010-04-01) |
Veröffentlichung: | Wiley, 2010 |
Medientyp: | unknown |
ISSN: | 1530-6860 (print) ; 0892-6638 (print) |
DOI: | 10.1096/fasebj.24.1_supplement.lb24 |
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