Gastrointestinal Tract Adverse Events
In: Advances in Experimental Medicine and Biology ISBN: 9783030410070; (2020)
Online
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Zugriff:
Immune checkpoint inhibitors (ICIs) have shown significant benefit in cancer patients. Their success, however, is associated with immune-related adverse events (irAEs), which commonly affect the gastrointestinal tract, resulting in diarrhea and colitis. IrAEs range from mild self-limiting to severe life-threatening diseases and potentially limit the use of these medications. Diagnosis of ICI-induced enterocolitis is based on clinical symptoms, physical examination, stool tests, endoscopic and histologic evaluation, and/or imaging. Current management strategy is mainly anti-diarrheal agents for mild symptoms and immunosuppressants (e.g., corticosteroids, and infliximab or vedolizumab) for more severe diseases.
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Gastrointestinal Tract Adverse Events
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Autor/in / Beteiligte Person: | Wang, Yinghong ; Abu-Sbeih, Hamzah |
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Quelle: | Advances in Experimental Medicine and Biology ISBN: 9783030410070; (2020) |
Veröffentlichung: | Springer International Publishing, 2020 |
Medientyp: | unknown |
ISBN: | 978-3-030-41007-0 (print) |
DOI: | 10.1007/978-3-030-41008-7_12 |
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