ChemInform Abstract: Mild and Efficient DBU-Catalyzed Amidation of Cyanoacetates
In: ChemInform, Jg. 40 (2009-09-08)
Online
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Zugriff:
A mild, high-yielding, and practical protocol for the direct amidation of alkyl cyanoacetates using DBU is presented. This method eliminates the need for activation of cyanoacetic acid and/or high temperatures. It has been applied to the large-scale synthesis of CP-690,550-10 (1), a compound under development for the treatment of autoimmune diseases.
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ChemInform Abstract: Mild and Efficient DBU-Catalyzed Amidation of Cyanoacetates
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Autor/in / Beteiligte Person: | Hawkins, Joel M. ; Price, Kristin E. ; Lillie, Brett M. ; Larrivee‐Aboussafy, Claude ; Mustakis, Jason ; Robert William Mclaughlin ; Hettenbach, Kevin ; Vaidyanathan, Rajappa |
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Zeitschrift: | ChemInform, Jg. 40 (2009-09-08) |
Veröffentlichung: | Wiley, 2009 |
Medientyp: | unknown |
ISSN: | 1522-2667 (print) ; 0931-7597 (print) |
DOI: | 10.1002/chin.200936053 |
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