Bypassing human CoQ 10 deficiency
In: Molecular Genetics and Metabolism, Jg. 123 (2018-03-01), S. 289-291
Online
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Zugriff:
Primary disorders of the human coenzyme Q10 (CoQ10) biosynthesis pathway are a known cause of severe pediatric diseases. So far, oral administration of CoQ10 is the only treatment strategy for affected individuals. However, the real benefit of CoQ10 supplementation remains questionable and clinical studies regarding efficiency are lacking. Here we provide an outlook on novel treatment approaches using CoQ precursor compounds. These metabolic bypass strategies might be a promising alternative for oral CoQ10 supplementation regimens.
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Bypassing human CoQ 10 deficiency
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Autor/in / Beteiligte Person: | Herebian, Diran ; López, Luis C. ; Distelmaier, Felix |
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Zeitschrift: | Molecular Genetics and Metabolism, Jg. 123 (2018-03-01), S. 289-291 |
Veröffentlichung: | Elsevier BV, 2018 |
Medientyp: | unknown |
ISSN: | 1096-7192 (print) |
DOI: | 10.1016/j.ymgme.2017.12.008 |
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