Prognostic significance of preoperative NLR, PLR and LMR in patients suffering from gastric neuroendocrine tumor
Research Square Platform LLC, 2021
Online
unknown
Zugriff:
Background: The prognostic value of inflammatory response makers for predicting clinical outcome have been proved valid in various cancers.The aim of this study was to explore the influence of the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and lymphocyte-to-monocyte ratio(LMR) on the prognosis of gastric neuroendocrine tumor.Methods: One hundred and three patients who underwent curative surgery for gastric neuroendocrine tumor were enrolled form 2009-2018 in The first affiliated hospital of Anhui Medical University.NLR,PLR and LMR were calculated from peripheral blood cell counts taken before surgery.Optimal cutoff values of NLR,PLR and LMR were determined on the basis of receiver operating characteristic curve analysis,and their prognostic values were assessed using Kaplan-Meier curve,univariate and multivariate COX regression models.Result:The cutoff value of NLR,PLR and LMR was 2.08,147.5 and 3.94,respectively.Elevated NLR,PLR and declined LMR were found to relate with diminished Overall survival (OS) in surgical gNET patients.Multivariate analysis identified the LMR(HR=0.923 (0.860-0.991), P=0.027);tumor size(HR=1.130 (1.032-1.239),P = 0.009) and high grade postoperative complication(HR=2.847 (1.129-7.480), P =0.027) as independent prognostic factors.Conclusion: Inflammatory response markers can predict clinical outcome in patients with gNET,especially LMR might be considered as a convenient indicator for patients’ prognosis
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Prognostic significance of preoperative NLR, PLR and LMR in patients suffering from gastric neuroendocrine tumor
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Autor/in / Beteiligte Person: | Zou, Bing-bing ; Fang, Can |
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Veröffentlichung: | Research Square Platform LLC, 2021 |
Medientyp: | unknown |
DOI: | 10.21203/rs.3.rs-455688/v1 |
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