P226High platelets adrenoreactivity determines resistance to double antiplatelet therapy among patients with myocardial infarction
In: Cardiovascular Research, Jg. 103 (2014-06-27), S. S40.2
Online
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Zugriff:
Resistance to double antiplatelet therapy, impairing outcome of myocardial infarction (MI), is manifested by the hyperreactive platelets' phenotype as evaluated by high in vitro response to ADP. As patients with high adrenoreactivity belong to the group of high cardiovascular risk, it was reasonable to investigate whether high platelets' adrenoreactivity was responsible for resistance to P2Y12 blocking agents. Materials and Methods. Light transmission platelets aggregometry following ADP and epinephrine (Sigma) stimulation in EC50 (5mkM both) or subthreshold concentration (0.5mkM, 0.1 mkM respectively) was carried out on plasma of 39 patients with MI receiving double antiplatelet therapy. After evaluating platelets' response to epinephrine and distributing patients into two groups (response less/more than 50%), they were compared on the basis of their response to ADP. Further, influence of subthreshold concentration of epinephrine and ADP on the overall platelets' reactivity was analysed. MedCalc sowtware was used for statistical analysis. Results: A strong correlation existed between a high response to epinephrine and ADP (r=0.64, p=0.0002); moreover, two groups differed on the basis of their response to ADP (p=0.0017). Thus, platelets' adrenoreactivity influenced overall responsiveness to antiplatelet therapy as measured by response to ADP. Since a hypoxic tissue releases ADP to the regional microcirculation, and, furthermore, since MI is accompanied by a high level of catecholamines in plasma, it was reasonbale to investigate whether a high response to the combination of those two agonists in low doses determined the hyperreactive platelets' phenotype. It was revealed that a strong correlation existed between a high platelet reactivity as measured with the help of EC50 of epinephrine, and their high response (more than 50%) to the pair of ADP and epinephrine (r=0.73). In conclusion, high platelets' adrenoreactivity determines resistance to double antiplatelet therapy among patients with myocardial infarction.
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P226High platelets adrenoreactivity determines resistance to double antiplatelet therapy among patients with myocardial infarction
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Autor/in / Beteiligte Person: | Sulaieva, Oksana ; Gatina, KI |
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Zeitschrift: | Cardiovascular Research, Jg. 103 (2014-06-27), S. S40.2 |
Veröffentlichung: | Oxford University Press (OUP), 2014 |
Medientyp: | unknown |
ISSN: | 1755-3245 (print) ; 0008-6363 (print) |
DOI: | 10.1093/cvr/cvu082.159 |
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