Efficient synthesis of N-protected amino/peptide Weinreb amides from T3P and DBU
In: Tetrahedron Letters, Jg. 54 (2013-02-01), S. 478-482
Online
unknown
Zugriff:
The reaction of N a -protected amino/peptide acid with N,O-dimethylhydroxylamine hydrochloride in the presence of T3P and DBU to obtain enantiomerically pure N a -protected amino/peptidyl Weinreb amides in high yields has been described. Fmoc-Ala-Weinreb amide 2a is obtained as single crystal, and its structure was determined through X-ray crystallography.
Titel: |
Efficient synthesis of N-protected amino/peptide Weinreb amides from T3P and DBU
|
---|---|
Autor/in / Beteiligte Person: | Nagendra, G. ; Vishwanatha, T. M. ; Sureshbabu, Vommina V. ; Sharnabai, K. M. |
Link: | |
Zeitschrift: | Tetrahedron Letters, Jg. 54 (2013-02-01), S. 478-482 |
Veröffentlichung: | Elsevier BV, 2013 |
Medientyp: | unknown |
ISSN: | 0040-4039 (print) |
DOI: | 10.1016/j.tetlet.2012.11.064 |
Schlagwort: |
|
Sonstiges: |
|