Sesquiterpenoids from the Rhizomes of Curcuma phaeocaulis and Their Inhibitory Effects on LPS-Induced TLR4 Activation
In: CHEMICAL & PHARMACEUTICAL BULLETIN, Jg. 64 (2016), S. 1062-1066
Online
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Zugriff:
Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.
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Sesquiterpenoids from the Rhizomes of Curcuma phaeocaulis and Their Inhibitory Effects on LPS-Induced TLR4 Activation
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Autor/in / Beteiligte Person: | Lee, Soyoung ; Seung Woong Lee ; Jang, Hyun-Jae ; Kim, Jin-Han ; Kim, Min-Suk ; Jung, Kyungsook ; Rho, Mun-Chual ; Young Ho Kim ; Oh, Hyun-Mee ; Woo Song Lee ; Jin Ha Jo |
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Zeitschrift: | CHEMICAL & PHARMACEUTICAL BULLETIN, Jg. 64 (2016), S. 1062-1066 |
Veröffentlichung: | Pharmaceutical Society of Japan, 2016 |
Medientyp: | unknown |
ISSN: | 1347-5223 (print) ; 0009-2363 (print) |
DOI: | 10.1248/cpb.c16-00086 |
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