Impact of hemodialysis on clinical and angiographic outcomes in in-stent restenotic lesions following optical coherence tomography-guided drug-coated balloon treatment
In: Cardiovascular Intervention and Therapeutics, Jg. 36 (2020-10-13), S. 429-435
Online
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Zugriff:
Hemodialysis (HD) is associated with a high in-stent restenosis (ISR) rate even in the second-generation era. Drug-coated balloons (DCB) generally provide excellent clinical outcomes in patients with ISR lesions. Nonetheless, safety and efficacy of DCB for ISR lesions in HD patients are largely unknown. A total of 17 centers across Japan participated in this study. Patients were eligible for the study if ISR lesions were treated with DCB. Enrolled patients were divided into 2 groups (HD and non-HD groups). Angiographic, OCT, and clinical outcomes were compared between the HD and the non-HD groups. A total of 210 patients were enrolled (36 patients in the HD group, and 174 patients in the non-HD group). At 8 months, the binary restenosis rate was significantly higher (26.3% versus 11.3%, p = 0.02) and in-segment late loss was significantly higher (0.49 ± 0.61 mm versus 0.23 ± 0.33 mm, p = 0.02) in the HD group than the non-HD group. In the OCT analyses, change of minimum stent area between post- and pre-procedure was significantly smaller in the HD group compared to the non-HD group (0.08 ± 0.95 mm2 versus 0.68 ± 1.07 mm2, p = 0.004). Target vessel failure (TVF) rate at 2 years was significantly different between the 2 groups (25.0% in the HD group and 12.1% in the non-HD group, p = 0.04). In the multivariate analysis, HD was a significant predictor for TVF (Hazard ratio 5.81, 95% CI 1.28–26.4, p = 0.02). Clinical and angiographic outcomes following OCT-guided DCB treatment in ISR lesions were significantly worse in HD patients compared to non-HD patients. Clinical Trial Registration Information: https://clinicaltrials.gov/ct2/show/NCT02300454
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Impact of hemodialysis on clinical and angiographic outcomes in in-stent restenotic lesions following optical coherence tomography-guided drug-coated balloon treatment
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Autor/in / Beteiligte Person: | Ando, Kenji ; investigators, Elegant ; Ako, Junya ; Hibi, Kiyoshi ; Fujii, Kenshi ; Ikuta, Akihiro ; Zen, Kan ; Tobaru, Tetsuya ; Aoki, Jiro ; Habara, Maoto ; Nakamura, Shigeru ; Nakazawa, Gaku ; Sakurada, Masami ; Ozaki, Shunsuke ; Fusazaki, Tetsuya ; Asano, Taku ; Okada, Hisayuki ; Kozuma, Ken |
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Zeitschrift: | Cardiovascular Intervention and Therapeutics, Jg. 36 (2020-10-13), S. 429-435 |
Veröffentlichung: | Springer Science and Business Media LLC, 2020 |
Medientyp: | unknown |
ISSN: | 1868-4297 (print) ; 1868-4300 (print) |
DOI: | 10.1007/s12928-020-00718-7 |
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