Impact of lymph node ratio (LNR) on prognosis of early breast cancer
In: Journal of Clinical Oncology, Jg. 31 (2013-05-20), S. 1115-1115
Online
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Zugriff:
1115 Background: Breast cancer is currently staged according to the TNM (tumors, nodes, metastases) classification of the American Joint Committee on Cancer (AJCC) Staging System. Lymph node ratio (LNR, the ratio of positive axillary lymph nodes to the total number of nodes examined) may provide additional prognostic information to that provided by TNM scores. Furthermore, LNR may potentially identify subpopulations within the traditional AJCC stages that are at increased risk of adverse outcomes. Methods: We performed a single institution retrospective study of all patients diagnosed with early breast cancer between January 2000 and January 2011. Patients were divided into low- (≤0.14), intermediate- (0.15-0.39) and high-risk (≥0.4) LNR groups. We assessed the impact of LNR and conventional AJCC staging parameters on overall survival (OS) and disease-free survival (DFS). Results: 786 patients were included in the analsyis, 238 of whom were node positive. As expected nodal status according to pathologic nodal (pN) stage was prognostic for OS and DFS with OS decreasing from 88.3% in pN1 patients to 40.8% in those with pN3 disease (p
| Titel: |
Impact of lymph node ratio (LNR) on prognosis of early breast cancer
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| Autor/in / Beteiligte Person: | O'Hanlon, Deirdre ; O'Connor, Derbrenn ; Donnellan, Eoin ; Brian Richard Bird ; Murphy, Conleth G. ; O'Keefe, Jo |
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| Zeitschrift: | Journal of Clinical Oncology, Jg. 31 (2013-05-20), S. 1115-1115 |
| Veröffentlichung: | American Society of Clinical Oncology (ASCO), 2013 |
| Medientyp: | unknown |
| ISSN: | 1527-7755 (print) ; 0732-183X (print) |
| DOI: | 10.1200/jco.2013.31.15_suppl.1115 |
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