Reduction of CX to CHXH by Hydride Delivery from Carbon
Elsevier, 1991
Online
unknown
Zugriff:
Unanticipated developments help to put known facts into place. Results from biochemistry drove home to organic chemists the message that it was not a chemical rarity for carbon-hydrogen bonds to be sources of hydride equivalents. Westheimer, Vennesland et al.1 established beyond doubt that in a redox reaction mediated by the coenzyme couple NAD(P)+/NAD(P)H the carbon-hydrogen bond of ethanol could serve directly as a hydride donor to an electron-deficient carbon of a pyridinium ion, and that this hydride equivalent could in turn be donated directly to the electropositive carbon of a carbonyl group. Thus the hydride donor capacities of carbon are also part and parcel of life. All this can occur under physiological conditions with the help of an enzyme, which somehow activates these reactants. The sequence is illustrated schematically in equation (1). In either direction hydride is transferred from carbon to carbon.
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Reduction of CX to CHXH by Hydride Delivery from Carbon
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Autor/in / Beteiligte Person: | Kellogg, Richard M. |
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Veröffentlichung: | Elsevier, 1991 |
Medientyp: | unknown |
DOI: | 10.1016/b978-0-08-052349-1.00219-5 |
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