Effect of herbal medicine (Sho-seiryu-to and Ryo-kan-kyo-mi-shin-ge-nin-to) on human eosinophil biological function
In: Phytotherapy Research, Jg. 11 (1997-11-01), S. 485-489
Online
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Zugriff:
The effects were examined of Sho-seiryu-to and Ryo-kan-mi-shin-ge-nin-to on the degranulation, expression of adhesion molecules and viability of human eosinophils. Eosinophil degranulation by granulocyte/macrophage-colony stimulating factor (GM-CSF) and platelet activating factor (PAF) was significantly inhibited in a dose dependent fashion by Sho-seiryu-to and Ryo-kan-kyo-mi-shin-ge-nin-to. Mean fluorescence intensity (MFI) of constitutively expressed CD11b/CD18 on eosinophils was augmented by GM-CSF or PAF stimulation; however, the increased CD11b/CD18 expression on eosinophils was significantly down-regulated by Sho-seiryu-to. Eosinophil survival in the presence of recombinant human interleukin-5 in vitro was significantly inhibited by 1000 μg/mL of Sho-seiryu-to and Ryo-kan-kyo-mi-shin-ge-nin-to, which possess an inhibitory effect on eosinophil function, suggesting their usefulness in the treatment of allergic diseases. © 1997 John Wiley & Sons, Ltd.
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Effect of herbal medicine (Sho-seiryu-to and Ryo-kan-kyo-mi-shin-ge-nin-to) on human eosinophil biological function
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Autor/in / Beteiligte Person: | Okubo, Yoshio ; Momose, Tomoyasu ; Horie, Shiro ; Hossain, Mahboob ; Suzuki, Jun-ichi ; Sekiguchi, Morie ; Isobe, Mitsuaki |
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Zeitschrift: | Phytotherapy Research, Jg. 11 (1997-11-01), S. 485-489 |
Veröffentlichung: | Wiley, 1997 |
Medientyp: | unknown |
ISSN: | 1099-1573 (print) ; 0951-418X (print) |
DOI: | 10.1002/(sici)1099-1573(199711)11:7<485::aid-ptr133>3.0.co;2-n |
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