Експресія мРНК галектину-9 при ожирінні у дітей з поліморфізмами гена лактази
In: CHILD`S HEALTH, Jg. 13 (2021-09-20), S. 12-18
Online
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Zugriff:
Background. The aim of the study is to investigate the association of expression of galectin-9 (Gal-9) mRNA and lactose malabsorption in obese children with polymorphism (SNP) of the lactase gene (LCT) and to study the efficacy of lactase deficiency therapy using exogenous lactase preparations. Materials and methods. Seventy obese children (BMI > 95 th percentile) and 16 children without obesity aged 6–18 years were examined. There was studied SNP LCT (material for investigation venous blood) by real-time PCR, expression of Gal-9 mRNA (study material buccal epithelium) by real-time PCR with reverse transcription, malabsorption of lactose by hydrogen breath test (HBT). Among obese children, 38 children with genotype C/C 13910 presented the first observation group, 32 children with phenotype identical genotypes C/T 13910 and T/T 13910, p > 0.05, presented the second group. Children from the first observation group also determined the level of expression of Gal-9 mRNA and lactose malabsorption after using exogenous lactase preparations. Results. The genotype C/C 13910 was determined in 38 (54.3 %), genotype C/T 13910 in 22 (31.4 %) and genotype T/T in 10 (14.3 %) patients. Malabsorption of lactose in children with genotype C/C 13910 averaged 32.7 ± 10.4 pmm, in children with genotypes C/T 13910 — 26.3 ± 4.9 pmm (p > 0.05) and with genotype T/T 13910 and was absent in children without obesity (p
Titel: |
Експресія мРНК галектину-9 при ожирінні у дітей з поліморфізмами гена лактази
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Autor/in / Beteiligte Person: | Dosenko, V.E. ; Nikulina, A.A. ; Abaturov, A.E. |
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Zeitschrift: | CHILD`S HEALTH, Jg. 13 (2021-09-20), S. 12-18 |
Veröffentlichung: | Publishing House Zaslavsky, 2021 |
Medientyp: | unknown |
ISSN: | 2307-1168 (print) ; 2224-0551 (print) |
DOI: | 10.22141/2224-0551.13.1.2018.127060 |
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