Ventilation of Ambulatory Rats Exposed to Methanol Vapor in a Flow-Through Exposure System: Measurement and Input to Toxicokinetic Models
In: Inhalation Toxicology, Jg. 8 (1996), S. 143-162
Online
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Zugriff:
Ventilation parameters (minute ventilation, V; tidal volume, Vt; and breathing frequency, f) of female Sprague-Dawley rats were measured during an 8-h exposure to methanol vapor at concentrations of 1000, 5000, 10, 000, 15, 000 and 20, 000 ppm. Rats were exposed individually in a flow-through chamber that permitted simultaneous measurement of ventilation, methanol extraction from the airstream by the animal, and blood methanol concentration. Compared to the whole-body plethysmography with nose-only exposure (WBP) system, the total ventilation of rats in this study was approximately half; the Vt was approximately the same, but f was about 50% lower than reported in WBP exposed rats. The hourly ventilation decreased slightly with increasing blood methanol concentration up to 2000 mg/L; at concentrations exceeding 2000 mg/L, the hourly ventilation decreased more significantly. The exposure system method studied simultaneously yielded information on the extraction of methanol from the airstream, effi...
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Ventilation of Ambulatory Rats Exposed to Methanol Vapor in a Flow-Through Exposure System: Measurement and Input to Toxicokinetic Models
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Autor/in / Beteiligte Person: | Perkins, Robert A. ; Pollack, Gary M. ; Ward, Keith W. |
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Zeitschrift: | Inhalation Toxicology, Jg. 8 (1996), S. 143-162 |
Veröffentlichung: | Informa UK Limited, 1996 |
Medientyp: | unknown |
ISSN: | 1091-7691 (print) ; 0895-8378 (print) |
DOI: | 10.3109/08958379609046560 |
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