CMOS-based Florescence Biosensor with Integrated Nanoplasmonic Filters

Fluorescence-based bimolecular sensing is one of the most prevalent methods for diagnostics, but typically requires complex optical instrumentation to detect weak fluorescence signal in presence of excitation light for sensitive assays. In this work, we present the first integrated biosensor chip, fabricated in standard complementary-metal-oxide (CMOS) technology with integrated copper-based nanoplasmonic filters that allows elimination of all external optical instruments and encompasses the sensing platform, sensors, scanner in a mm-sized CMOS chip.