Receptor-Mediated Endocytosis of (Mixed-Lipid) Dispersed LMN
Elsevier, 2011
Online
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Zugriff:
Overlap of lipid composition exists among high-density lipoprotein (HDL), low-density lipoprotein (LDL), modified LDL, lipid-coated microbubble (LCM), and dispersed lipid-mesophase nanoparticle (LMN). This overlap suggests that LCM and/or dispersed LMN themselves can act as ligands for multiligand lipoprotein receptors. In particular, the multiligand scavenger receptor (i.e., SR-BI) is known to bind both HDL and LDL particles. Accordingly, SR-BI represents the most likely candidate involved in enhanced endocytosis of “LCM/nanoparticle-derived” lipid nanoemulsions (i.e., mostly dispersed LMN) into tumor cells. Moreover, the overlap of lipid composition between HDL, LDL, modified LDL, LCM, and LMN can partially mimic the known heterogeneity (i.e., subpopulations or subspecies) of LDL and HDL particles.
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Receptor-Mediated Endocytosis of (Mixed-Lipid) Dispersed LMN
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Autor/in / Beteiligte Person: | D'Arrigo, Joseph |
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Veröffentlichung: | Elsevier, 2011 |
Medientyp: | unknown |
DOI: | 10.1016/b978-0-444-53798-0.00026-2 |
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