Coronary artery calcification and vascular function
In: Journal of Nuclear Cardiology, Jg. 19 (2012-01-31), S. 227-229
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Danad et al’s work reported in this issue adds to the growing evidence questioning the strength and the nature of the relationship between the anatomic magnitude of coronary atherosclerosis and its functional consequences on myocardial perfusion. The FAME trial demonstrated that for patients with overt coronary stenosis, a functional flow-guided approach leads to better outcomes than one based on anatomic measurements of stenosis severity. At the opposite end of the spectrum of coronary atherosclerosis, the work of Danad et al explores the relationship between calcified coronary atherosclerosis and perfusion among patients without overt coronary stenosis. Confirming work previously reported using other methods, this article demonstrates that, among 173 patients referred for combined O-water PET and coronary artery computed tomography, there is a statistically significant inverse correlation between the degree of coronary artery calcification (CAC) and the myocardial blood flow (MBF) or the coronary flow reserve (CFR). However, as in prior studies, the magnitude of the correlation is modest. Furthermore, the observed association completely disappeared after correction for traditional clinical risk factors, suggesting that the observed association between myocardial perfusion and coronary artery calcification is largely due to overlapping clinical risk factors. The lack of an observed independent relation between MBF and CAC suggests that no discernible relation exists or that the effect size of the relation is too small to be detected by the given sample size and technique used. The current study used O-labeled water, the optimal radiotracer for measuring myocardial blood flow. The authors also studied longitudinal apex to base gradient, a measure of the hemodynamic effects of diffuse coronary atherosclerosis. Importantly, prior studies did not rigorously exclude the presence of epicardial coronary stenosis, relying on normal relative perfusion imaging to identify subjects unlikely to have obstructive epicardial coronary lesions. Despite these efforts, it is possible that these prior studies enrolled patients who had obstructive epicardial stenoses which would result in abnormal calcium scores and quantitative myocardial perfusion. In contrast, Danad et al rigorously excluded obstructive lesions using either invasive or CT coronary angiography. By doing so, this study is able to explore the effects of coronary calcification on the combined hemodynamic effects of impaired vasodilator function in both non-obstructive epicardial coronary arteries and microvascular dysfunction. Additional studies would be required to separate contributions of these two components of circulatory dysfunction. Indeed, one potential reason for the lack of association in the study by Danad et al that some of the patients with abnormal CFR had exclusively microvascular dysfunction with truly normal epicardial arteries lacking calcifications. The frequency of this pattern is unfortunately not specified in their work. The use of rigorous, gold-standard methodologies, and concordance with prior studies suggests that the primary finding of this study, i.e., the lack of an independent relationship between CAC and CFR, is likely to be true. Although the technical methods of this article are laudable, it should be kept in mind that only 29 of the 173 subjects had a CAC of C100. Also, as the authors acknowledge, the study cohort was too small for subgroup analysis based on CAC categories. Nonetheless, the distribution of CAC in this study likely reflects clinical reality in symptomatic patients without obstructive CAD. Further, the study does not explore the frequency of abnormal MBF among patients with low or zero CAC. These patients would not generally be treated with CAD risk reduction therapies based on CAC but might be considered for prevention medications on the From the Division of Cardiovascular Imaging, Department of Radiology, Division of Cardiovascular Diseases, Department of Medicine, Division of Nuclear Medicine, Department of Radiology, Brigham and Women’s Hospital, Boston, MA. Reprint requests: Sharmila Dorbala, MD, MPH, FACC, Division of Nuclear Medicine, Department of Radiology, Brigham and Women’s Hospital, 75 Francis Street, ASB1, L-1, Boston, MA 02115; sdorbala@partners.org. J Nucl Cardiol 2012;19:227–9. 1071-3581/$34.00 Copyright 2012 American Society of Nuclear Cardiology. doi:10.1007/s12350-011-9503-8
Titel: |
Coronary artery calcification and vascular function
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Autor/in / Beteiligte Person: | Murthy, Venkatesh L. ; Dorbala, Sharmila |
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Zeitschrift: | Journal of Nuclear Cardiology, Jg. 19 (2012-01-31), S. 227-229 |
Veröffentlichung: | Springer Science and Business Media LLC, 2012 |
Medientyp: | unknown |
ISSN: | 1532-6551 (print) ; 1071-3581 (print) |
DOI: | 10.1007/s12350-011-9503-8 |
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