Molecular subtypes, body mass index (BMI), and their time-varying prognostic impact in node-positive breast cancer (BC): Pooled analysis from the WSG AM-01 and -02 trials
In: Journal of Clinical Oncology, Jg. 29 (2011-05-20), S. 1021-1021
Online
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Zugriff:
1021 Background: Obesity has been reported to be associated with aggressive tumor characteristics and poor prognosis in early BC in mostly unselected collectives. This study was performed to investigate the prognostic impact of obesity taking into account molecular subtypes in randomized node-positive BC cohort treated by chemotherapy (Cht). Methods: Pooled analysis in 2353 patients was done using data from the WSG-AM-01 (high risk BC with >9 positive lymph nodes (LN), treated by either tandem high dose or dose-dense Cht) and AM-02 trials (intermediate risk BC with 1−3 positive LN treated by CEF/CMF or EC-Doc). Data on hormone receptors (HR) and HER2 were available in 2045 pts, molecular subtypes (luminal A vs. B (by Ki-67 or HER2), basal/non-basal triple negative (TN) BC and HER2) by central pathology review in 865 pts. Time-varying Cox proportional hazards regression models were used to assess the prognostic impact of BMI after adjusting for other factors. Results: Median follow up was 59 months. BMI wa...
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Molecular subtypes, body mass index (BMI), and their time-varying prognostic impact in node-positive breast cancer (BC): Pooled analysis from the WSG AM-01 and -02 trials
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| Autor/in / Beteiligte Person: | Kates, Ronald E. ; Liedtke, Cornelia ; Thomssen, C. ; Harbeck, Nadia ; Gluz, O ; Nitz, U. ; Moebus, Volker ; Huober, J ; Hartmann, Arndt ; Mohrmann, Svjetlana |
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| Zeitschrift: | Journal of Clinical Oncology, Jg. 29 (2011-05-20), S. 1021-1021 |
| Veröffentlichung: | American Society of Clinical Oncology (ASCO), 2011 |
| Medientyp: | unknown |
| ISSN: | 1527-7755 (print) ; 0732-183X (print) |
| DOI: | 10.1200/jco.2011.29.15_suppl.1021 |
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