Xanthohumol protects against Azoxymethane‐induced colorectal cancer in Sprague‐Dawley rats
In: Environmental Toxicology, Jg. 35 (2019-11-12), S. 136-144
Online
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Zugriff:
Colorectal cancer (CRC) is a major health problem and third most common deaths in western world. Dietary interventions together with modified dietary style can prevent the CRC in humans. Xanthohumol (XHA), a polyphenol isolated from Humulus lupulus L. contains many beneficial effects. The aim of the study is to analyze the effect of XHA on Azoxymethane (AOM)-induced experimental CRC in rats. Levels of MDA were increased and enzymic antioxidants levels were decreased in AOM-induced rats. However, these levels were reversed upon XHA treatment. Further, the mRNA expressions of iNOS and COX-2 were also downregulated in XHA treated rats compared to AOM-induced rats. Further, we found that administration of XHA suppressed the wnt/β-catenin signaling together with modulation of apoptotic proteins Bax, Bcl-2, and caspase 3. We conclude that XHA can able to quench the free radicals, inhibits cell proliferation and induces apoptosis, thus it can be a chemopreventive/therapeutic agent against CRC.
| Titel: |
Xanthohumol protects against Azoxymethane‐induced colorectal cancer in Sprague‐Dawley rats
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| Autor/in / Beteiligte Person: | Zhang, Lei ; Liu, Hualin ; Li, Guanghua ; Gao, Zhuanglei |
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| Zeitschrift: | Environmental Toxicology, Jg. 35 (2019-11-12), S. 136-144 |
| Veröffentlichung: | Wiley, 2019 |
| Medientyp: | unknown |
| ISSN: | 1522-7278 (print) ; 1520-4081 (print) |
| DOI: | 10.1002/tox.22849 |
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