Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets for synergistically enhancing hemocompatibility and cytocompatibility and reducing calcification
In: Journal of Materials Chemistry B, Jg. 10 (2022), S. 8218-8234
Online
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Zugriff:
Clinically frequently-used glutaraldehyde (GA)-crosslinked bioprosthetic valve leaflets (BVLs) are still curbed by acute thrombosis, malignant immunoreaction, calcification, and poor durability. In this study, an anticoagulant heparin-like biomacromolecule, sulfonated, oxidized pectin (SAP) with a dialdehyde structure was first obtained by modifying citrus pectin with sulfonation of 3-amino-1-propane sulfonic acid and then oxidating with periodate. Notably, a novel crosslinking approach was established by doubly crosslinking BVLs with SAP and the nature-derived crosslinking agent quercetin (Que), which play a synergistic role in both crosslinking and bioactivity. The double crosslinked BVLs also presented enhanced mechanical properties and enzymatic degradation resistance owing to the double crosslinking networks formed
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Sulfonated, oxidized pectin-based double crosslinked bioprosthetic valve leaflets for synergistically enhancing hemocompatibility and cytocompatibility and reducing calcification
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Autor/in / Beteiligte Person: | Hu, Mengyue ; Peng, Xu ; Shi, Shubin ; Wan, Chang ; Cheng, Can ; Lei, Ningning ; Yu, Xixun |
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Zeitschrift: | Journal of Materials Chemistry B, Jg. 10 (2022), S. 8218-8234 |
Veröffentlichung: | Royal Society of Chemistry (RSC), 2022 |
Medientyp: | unknown |
ISSN: | 2050-7518 (print) ; 2050-750X (print) |
DOI: | 10.1039/d2tb01704k |
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