Occurrence of dentate granule cell LTP without proximal dendritic Ca2+ increase
In: NeuroReport, Jg. 10 (1999-08-01), S. 2509-2513
Online
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Zugriff:
We investigated activity-dependent calcium increases in proximal dendrites of dentate granule cells in the rat hippocampus, and its relationship with induction of LTP at perforant path synapses (PP-synapses). LTP was induced at PP-synapses by high-frequency stimulation (HFS; 100 Hz for 0.4 s), and the same HFS evoked a dendritic calcium increase in the proximal dendrite. However, bath-application of the L-type voltage-dependent calcium channel (VDCC) blocker nimodipine noticeably reduced this calcium increase without abolishing induction of LTP. This calcium increase mediated by high-threshold VDCCs is likely to be evoked by action potentials. LTP induction at PP-synapses is hence suggested to be independent of action potential-induced calcium increases in the proximal dendrite.
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Occurrence of dentate granule cell LTP without proximal dendritic Ca2+ increase
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Autor/in / Beteiligte Person: | Hashimoto, Kenji ; Kato, Nobuo ; Isomura, Yoshikazu |
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Zeitschrift: | NeuroReport, Jg. 10 (1999-08-01), S. 2509-2513 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 1999 |
Medientyp: | unknown |
ISSN: | 0959-4965 (print) |
DOI: | 10.1097/00001756-199908200-00014 |
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