Expansion of corticomedullary junction high-susceptibility region (CMJ-HSR) with aging: a clue in the pathogenesis of Alzheimer's disease?
In: Journal of neuroimaging : official journal of the American Society of Neuroimaging, Jg. 22 (2011-06-25), Heft 4
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Zugriff:
BACKGROUND Susceptibility-weighted imaging (SWI) microscopy on a 7.0T system demonstrated the corticomedullary junction (CMJ) to be a high-susceptibility region (HSR) in young normal subjects, suggesting that functional alteration of cortical microcirculation could be assessed with this imaging method. METHODS Focused microscopic studies were performed on the parietal association cortex in 74 normal volunteers (ages 20-79 years; 35 female, 39 male) using a SWI algorithm on a system constructed based on General Electric Signa LX (Waukesha, WI, USA), equipped with a 900-mm clear bore superconducting magnet operating at 7.0T. RESULTS There was a clear-cut reduction in the thickness of the normal-appearing cortex (cortex, R2= .5290, P < .001) and expansion of CMJ-HSR (R2= .6919, P < .001). The sum of cortex thickness and CMJ-HSR thickness was essentially constant, suggesting that the observed expansion of CMR-HSR with aging likely occurred within the cortical mantle. CONCLUSION CMJ-HSR expands significantly as a function of aging. Since CMJ-HSR represents a functionally distinct area with relatively slow venous flow, the observed expansion is believed to reflect alteration in cerebral microcirculation with increased age, providing another clue for pathogenesis of Alzheimer's disease.
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Expansion of corticomedullary junction high-susceptibility region (CMJ-HSR) with aging: a clue in the pathogenesis of Alzheimer's disease?
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Autor/in / Beteiligte Person: | Igarashi, Hironaka ; Nakada, Tsutomu ; Matsuzawa, Hitoshi ; Kwee, Ingrid L. |
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Zeitschrift: | Journal of neuroimaging : official journal of the American Society of Neuroimaging, Jg. 22 (2011-06-25), Heft 4 |
Veröffentlichung: | 2011 |
Medientyp: | unknown |
ISSN: | 1552-6569 (print) |
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