Altered Expression of Insulin Signaling Components in Streptozotocin-Treated Rats
In: Biochemical and Biophysical Research Communications, Jg. 212 (1995-07-01), S. 933-938
Online
unknown
Zugriff:
Insulin signaling is known to proceed through the insulin receptor to the insulin receptor substrate-1 (IRS-1). Tyrosine-phosphorylation of IRS-1 causes it to associate with the src-homology-2 (SH2) domains of at least four other proteins: phosphatidylinositol 3'-kinase (PI3K), growth factor receptor-bound protein-2 (GRB2), Nck, and Syp. In order to understand the cellular derangements associated with type I diabetes, the levels of these four SH2-containing proteins was determined in streptozotocin-induced diabetic rats. In liver tissue of diabetic rats, the levels of Nck and Syp were significantly decreased to 71 +/- 6% and 61 +/- 4% control, respectively, while in fat tissue only the Syp levels were significantly reduced to 72 +/- 9% control. PI3K levels were higher in livers of diabetic rats than controls, but unchanged in fat. The insulin-deficient diabetic condition was thus associated with altered levels of insulin signaling components.
Titel: |
Altered Expression of Insulin Signaling Components in Streptozotocin-Treated Rats
|
---|---|
Autor/in / Beteiligte Person: | Hofmann, Cecilia ; Bonini, J. A. ; Colca, Jerry R. |
Link: | |
Zeitschrift: | Biochemical and Biophysical Research Communications, Jg. 212 (1995-07-01), S. 933-938 |
Veröffentlichung: | Elsevier BV, 1995 |
Medientyp: | unknown |
ISSN: | 0006-291X (print) |
DOI: | 10.1006/bbrc.1995.2059 |
Schlagwort: |
|
Sonstiges: |
|