Synthesis of novel ��-aminophosphonates by methanesulfonic acid catalyzed Kabachnik���Fields reaction
Taylor & Francis, 2021
Online
unknown
Zugriff:
A series of novel ��-aminophosphonates of diethyl (2,4-difluorobenzylamino)methylphosphonate derivatives (4a���4g) have been synthesized by applying three-component Kabachnik���Fields reaction, using fluoro derivatives of aldehydes and substituted amines, diethyl phosphonate in the presence of a catalytic amount of methanesulfonic acid (MSA) in good yields with high enantioselectivities (up to 98% ee). The enantioselectivitiy of compounds (4a���4g) was confirmed by chiral HPLC. The direct Kabachnik���Fields reaction with high reactivity under mild reaction conditions and significantly used for synthesis of the ��-aminophosphonate. The novel products were characterized by spectral and analytical data.
Titel: |
Synthesis of novel ��-aminophosphonates by methanesulfonic acid catalyzed Kabachnik���Fields reaction
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Autor/in / Beteiligte Person: | Ravi, Nuchu ; Venkatanarayana, Muvvala ; Sharathbabu, Haridasyam ; Babu, Kilaru Ravendra |
Link: | |
Veröffentlichung: | Taylor & Francis, 2021 |
Medientyp: | unknown |
DOI: | 10.6084/m9.figshare.15156101 |
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