Effect of Sitagliptin on Coronary Flow Reserve Assessed by Magnetic Resonance Imaging in Type 2 Diabetic Patients With Coronary Artery Disease
In: Circulation journal : official journal of the Japanese Circulation Society, Jg. 82 (2018-05-16), Heft 8
Online
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Zugriff:
Background The present study was conducted to assess the cardiovascular effects of dipeptidyl peptidase-4 inhibitors (DPP4i) on coronary flow reserve (CFR), left ventricular (LV) function and endothelial function of the peripheral artery by comparison with those of α-glucosidase inhibitors (αGI) in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD).Methods and Results:We randomly assigned 30 patients with T2DM and CAD to receive either sitagliptin or voglibose, and 28 patients (age 69±9 years, 75% male, hemoglobin A1c [HbA1c] 6.62±0.48%) completed the study (14 in each group). CFR and LV function, assessed by cardiac magnetic resonance imaging, and endothelial function, assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT), were measured at baseline and 24 weeks after treatment. Clinical and laboratory parameters, including HbA1c level, plasma active glucagon-like peptide-1 concentrations, and biomarkers of inflammation, were unchanged in both groups after 24 weeks of treatment. CFR were unchanged in both the αGI group (3.01±0.98 at baseline and 3.06±0.8 after treatment, P=NS) and the DPP4i group (4.29±2.04 at baseline and 3.63±1.31 after treatment, P=NS), with no interaction effect. LV functional parameters and the reactive hyperemia index also remained unchanged after the 24-week treatment. Conclusions DPP4i did not improve CFR, LV function or endothelial function of the peripheral artery in patients with relatively well-controlled T2DM and CAD.
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Effect of Sitagliptin on Coronary Flow Reserve Assessed by Magnetic Resonance Imaging in Type 2 Diabetic Patients With Coronary Artery Disease
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Autor/in / Beteiligte Person: | Nakamura, Mashio ; Masuda, Jun ; Sato, Yuichi ; Yamada, Norikazu ; Sawai, Toshiki ; Nakamori, Shiro ; Ishida, Masaki ; Moriwaki, Keishi ; Takeuchi, Tetsushiro ; Dohi, Kaoru ; Fujimoto, Naoki ; Sakuma, Hajime ; Ito, Masaaki ; Kumagai, Naoto |
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Zeitschrift: | Circulation journal : official journal of the Japanese Circulation Society, Jg. 82 (2018-05-16), Heft 8 |
Veröffentlichung: | 2018 |
Medientyp: | unknown |
ISSN: | 1347-4820 (print) |
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