Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response
In: Nature Communications Nature Communications, Jg. 12 (2021), Heft 1, S. 1-11
Online
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Zugriff:
Transfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been mixed, potentially due to the heterogeneous nature of CP. Here we perform deep profiling of SARS-CoV-2-specific antibody titer, Fc-receptor binding, and Fc-mediated functional assays in CP units, as well as in plasma from hospitalized COVID-19 patients before and after CP administration. The profiling results show that, although all recipients exhibit expanded SARS-CoV-2-specific humoral immune responses, CP units contain more functional antibodies than recipient plasma. Meanwhile, CP functional profiles influence the evolution of recipient humoral immunity in conjuncture with the recipient’s pre-existing SARS-CoV2-specific antibody titers: CP-derived SARS-CoV-2 nucleocapsid-specific antibody functions are associated with muted humoral immune evolution in patients with high titer anti-spike IgG. Our data thus provide insights into the unexpected impact of CP-derived functional anti-spike and anti-nucleocapsid antibodies on the evolution of SARS-CoV-2-specific response following severe infection.
Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to find CP-mediated, spike/nucleocapsid-focused modulations of humoral responses in the recipient.
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Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response
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Autor/in / Beteiligte Person: | Bar, Katharine J. ; Herman, Jonathan D. ; M. Eugenia Dieterle ; Haslwanter, Denise ; Bortz, Robert H. ; Alter, Galit ; Chandran, Kartik ; Hyun Ah Yoon ; Wang, Chuangqi ; Julg, Boris ; Lauffenburger, Douglas A. ; Rivera, Johanna ; Liise Anne Pirofski ; Loos, Carolin ; Jangra, Rohit K. |
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Zeitschrift: | Nature Communications Nature Communications, Jg. 12 (2021), Heft 1, S. 1-11 |
Veröffentlichung: | Nature Publishing Group UK, 2021 |
Medientyp: | unknown |
ISSN: | 2041-1723 (print) |
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