Evaluation of serum free fatty acids in chronic renal failure: evidence from a rare case with undetectable serum free fatty acids and population data
In: Lipids in Health and Disease Lipids in Health and Disease, Jg. 18 (2019), Heft 1, S. 1-9
Online
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Zugriff:
Background Free fatty acid (FFA) accumulation in proximal tubules plays a fundamental role in the progress of kidney disease. Here, we reported a rare case with undetectable serum FFAs and further evaluated the changes of serum FFAs in patients with chronic renal failure (CRF). Methods We analyzed the clinical data of a rare case and 574 CRF patients. The mRNA expression of lipoprotein lipase (LPL), hepatic lipase (HL) and fatty acid synthase (FASN) were determined in the rare case and 30 age-matched healthy males with qPCR. Results This rare case had serious proteinuria, hyperglycemia, lipid disorders and bilateral renal glomerular filtration dysfunction. Compared with healthy males, this case showed a 1.49-fold increase of LPL expression (P 0.05). In total, 21.6% of CRF patients showed abnormal FFAs. Biochemical parameters such as blood urea nitrogen (BUN) and creatinine (CREA) significantly differed among groups with low-, normal- or high-level-FFAs. Moreover, serum FFAs was found to be associated with BUN. FFAs decreased in the group with higher BUN (> 17.4 mmol/L) and in the group with lower estimated glomerular filtration rate (eGFR) (
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Evaluation of serum free fatty acids in chronic renal failure: evidence from a rare case with undetectable serum free fatty acids and population data
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Autor/in / Beteiligte Person: | Zhou, Xin ; Liu, Song-Mei ; Liu, Zhen-Xian ; Yu, Wen-Li ; Peng, Ding-Hui ; Hong, Qian ; Shui, Hua ; Yang, Ying |
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Zeitschrift: | Lipids in Health and Disease Lipids in Health and Disease, Jg. 18 (2019), Heft 1, S. 1-9 |
Veröffentlichung: | Springer Science and Business Media LLC, 2019 |
Medientyp: | unknown |
ISSN: | 1476-511X (print) |
DOI: | 10.1186/s12944-019-1093-5 |
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