Effect of viologen–phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities
In: International Journal of Biological Macromolecules, Jg. 54 (2013-03-01), S. 119-124
Online
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Zugriff:
0141-8130; The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is the first step in checking whether new compounds can be considered as drugs for treating neurodegenerative diseases. The effect of viologen-phosphorus dendrimers on AChE and BChE activities was studied. The results show that the effects on the cholinesterase activities depend on dendrimer type and size. Viologen dendrimers can interact with the enzymes in two ways: they can bind either to a peripheral site of the enzyme or to amino acids located near the active site, inhibiting catalysis by both cholinesterases. All tested non-toxic viologen-phosphorus dendrimers inhibited the activities of both cholinesterases, showing their potential as new drugs for treating neurodegenerative diseases.
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Effect of viologen–phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities
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| Autor/in / Beteiligte Person: | Caminade, Anne-Marie ; Katir, Nadia ; Ciepluch, Karol ; Klajnert, Barbara ; Abdelkrim El Kadib ; Weber, Monika ; Bryszewska, Maria ; Majoral, Jean-Pierre ; Łódź University of Technology ; Laboratoire de chimie de coordination (LCC) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) ; Institute for Nanomaterials and Nanotechnology - INANOTECH (MOROCCO) |
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| Zeitschrift: | International Journal of Biological Macromolecules, Jg. 54 (2013-03-01), S. 119-124 |
| Veröffentlichung: | Elsevier BV, 2013 |
| Medientyp: | unknown |
| ISSN: | 0141-8130 (print) |
| DOI: | 10.1016/j.ijbiomac.2012.12.002 |
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