Short-Time Recurrences of Plasmodium vivax Malaria as a Public Health Proxy for Chloroquine-Resistance Surveillance: A Spatio-Temporal Study in the Brazilian Amazon
In: International Journal of Environmental Research and Public Health, Jg. 18 (2021-05-11), Heft 5061, p 5061, S. 5061-5061
Online
unknown
Zugriff:
In Brazil, malaria caused by Plasmodium vivax presents control challenges due to several reasons, among them the increasing possibility of failure of P. vivax treatment due to chloroquine-resistance (CQR). Despite limited reports of CQR, more extensive studies on the actual magnitude of resistance are still needed. Short-time recurrences of malaria cases were analyzed in different transmission scenarios over three years (2005, 2010, and 2015), selected according to malaria incidence. Multilevel models (binomial) were used to evaluate association of short-time recurrences with variables such as age. The zero-inflated Poisson scan model (scanZIP) was used to detect spatial clusters of recurrences up to 28 days. Recurrences compose less than 5% of overall infection, being more frequent in the age group under four years. Recurrences slightly increased incidence. No fixed clusters were detected throughout the period, although there are clustering sites, spatially varying over the years. This is the most extensive analysis of short-time recurrences worldwide which addresses the occurrence of P. vivax CQR. As an important step forward in malaria elimination, policymakers should focus their efforts on young children, with an eventual shift in the first line of malaria treatment to P. vivax.
Titel: |
Short-Time Recurrences of Plasmodium vivax Malaria as a Public Health Proxy for Chloroquine-Resistance Surveillance: A Spatio-Temporal Study in the Brazilian Amazon
|
---|---|
Autor/in / Beteiligte Person: | Antônio Alcirley da Silva Balieiro ; Vanderson de Souza Sampaio ; Villela, Daniel A. M. ; Gisely Cardoso de Melo ; Siqueira, André ; Mueller, Ivo ; Lacerda, Marcus V. G. ; Wuelton Marcelo Monteiro |
Link: | |
Zeitschrift: | International Journal of Environmental Research and Public Health, Jg. 18 (2021-05-11), Heft 5061, p 5061, S. 5061-5061 |
Veröffentlichung: | MDPI AG, 2021 |
Medientyp: | unknown |
ISSN: | 1660-4601 (print) |
DOI: | 10.3390/ijerph18105061 |
Schlagwort: |
|
Sonstiges: |
|