Epigenetic modifications of HIV proviral LTRs: potential targets for cure
In: Retrovirology, Jg. 9 (2012), Heft Suppl 1, S. O4
Online
unknown
Zugriff:
HIV-1 cure remains elusive despite HAART due to the reservoirs of proviral DNA integrated into the human genome. Efforts to cure HIV-1 therefore need to aim at eliminating proviral DNA from cellular reservoirs. The first epigenetic signal identified in virus infected and uninfected cells has been promoter methylation. Compelling evidence confirms that specific promoter methylation can lead to gene silencing. Previous studies have examined HIV-1-epigenetics mostly in vitro.
Titel: |
Epigenetic modifications of HIV proviral LTRs: potential targets for cure
|
---|---|
Autor/in / Beteiligte Person: | Weber, Stefanie ; Anastos, Kathryn ; Doerfler, Walter ; Weiser, Barbara ; Korn, Klaus ; Kimdar Sherefa Kemal ; Burger, Harold |
Link: | |
Zeitschrift: | Retrovirology, Jg. 9 (2012), Heft Suppl 1, S. O4 |
Veröffentlichung: | Springer Nature, 2012 |
Medientyp: | unknown |
ISSN: | 1742-4690 (print) |
DOI: | 10.1186/1742-4690-9-s1-o4 |
Schlagwort: |
|
Sonstiges: |
|