Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
In: Mol. Psychiatry 26, 3004–3017 (2021) Molecular Psychiatry Molecular Psychiatry, 26, pp. 3004-3017 Molecular Psychiatry, 26(7), 3004-3017. Nature Publishing Group Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ Molecular Psychiatry, 2020, ⟨10.1038/s41380-020-00898-x⟩ Molecular psychiatry, vol. 26, no. 7, pp. 3004-3017 Molecular Psychiatry, 26, 3004-3017
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Funding: AG and TFMA were supported by the Munich Cluster for Systems Neurology (SyNergy). AG 535 was supported by Fondazione Umberto Veronesi. SP is a Royal Society University Research fellow. BMM, CF, BSP and SEF are supported by the Max Planck Society. AW, BM and HK were funded by the Fraunhofer Society and the Max Planck Society within the ‘Pakt für Forschung und Innovation’. HK was also supported by LIFE – Leipzig Research Center for Civilization Diseases funded by means of the European Union; the European Regional Development Fund (ERDF); and the Free State of Saxony within the excellence initiative. FR is supported by Agence Nationale de la Recherche (ANR-06-NEURO-019-01, ANR-17-EURE-542 0017 IEC, ANR-10-IDEX-0001-02 PSL, ANR-11-BSV4-014-01), European Commission (LSHM-CT-2005-018696). TFMA was supported by the BMBF through the DIFUTURE consortium of the Medical Informatics Initiative Germany (grant 01ZZ1804A) and by the European Union’s Horizon 2020 Research and Innovation Programme (grant MultipleMS, EU RIA 733161). Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p
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Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
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| Autor/in / Beteiligte Person: | Brandeis, Daniel ; Mirza-Schreiber, Nazanin ; Pennington, Bruce F. ; Smith, Shelley D. ; Huguet, Guillaume ; Bonte, Milene ; Ramus, Franck ; Csépe, Valéria ; Andlauer, Till F. M. ; Paracchini, Silvia ; Wilcke, Arndt ; Paavo H.T. Leppänen ; Tóth, Dénes ; Nöthen, Markus M. ; Lyytinen, Heikki ; Becker, Jessica ; Bourgeron, Thomas ; Hulslander, Jacqueline ; Fisher, Simon E. ; Landerl, Karin ; Olson, Richard K. ; Müller-Myhsok, Bertram ; Fauchereau, Fabien ; Chaix, Yves ; Iannuzzi, Stéphanie ; Kere, Juha ; Démonet, Jean-François ; Czamara, Darina ; Vaessen, Anniek ; Beate St Pourcain ; Morris, Andrew P. ; Francks, Clyde ; Hoffmann, Per ; Peyrard-Janvid, Myriam ; Honbolygó, Ferenc ; DeFries, John C. ; Maurer, Urs ; Stein, John F. ; Scerri, Thomas S. ; Kirsten, Holger ; Talcott, Joel B. ; Schulte-Körne, Gerd ; Monaco, Anthony P. ; Gialluisi, Alessandro ; Willcutt, Erik G. ; Ludwig, Kerstin U. ; Müller, Bent ; Moll, Kristina ; Schumacher, Johannes ; STEMM - Stem Cells and Metabolism Research Program ; Juha Kere / Principal Investigator ; Research Programs Unit ; University of Helsinki ; Language ; RS: FPN CN 7 ; Max-Planck-Institut für Psychiatrie ; Max-Planck-Gesellschaft ; Munich Cluster for systems neurology [Munich] (SyNergy) ; Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU) ; Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.) ; Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II ; Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM) ; Helmholtz-Zentrum München (HZM) ; Ludwig-Maximilians-Universität München (LMU) ; University of Bonn ; Max Planck Institute for Psycholinguistics ; Radboud university [Nijmegen] ; University of Bristol [Bristol] ; Hungarian Academy of Sciences (MTA) ; Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)) ; Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS) ; Toulouse Neuro Imaging Center (ToNIC) ; Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse] ; CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse] ; Hôpital Purpan [Toulouse] ; CHU Toulouse [Toulouse] ; Université de Lausanne (UNIL) ; University of Liverpool ; University of Manchester [Manchester] ; University of Oxford [Oxford] ; University of Colorado [Boulder] ; University of Nebraska Medical Center ; University of Nebraska System ; University of Denver ; Maastricht University [Maastricht] ; The Chinese University of Hong Kong [Hong Kong] ; University of Jyväskylä (JYU) ; Karolinska Institutet [Stockholm] ; Universität Zürich [Zürich] = University of Zurich (UZH) ; Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich) ; Universität Heidelberg [Heidelberg] ; Aston University [Birmingham] ; Fraunhofer Institute for Cell Therapy and Immunology (Fraunhofer IZI) ; (Fraunhofer-Gesellschaft), Fraunhofer ; Universität Leipzig [Leipzig] ; Tufts University [Medford] ; Laboratoire de sciences cognitives et psycholinguistique (LSCP) ; Département d'Etudes Cognitives - ENS Paris (DEC) ; École normale supérieure - Paris (ENS Paris) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS) ; BioTechMed-Graz ; Graz University of Technology [Graz] (TU Graz)-University of Graz-Medical University Graz ; University of Melbourne ; University of St Andrews [Scotland] ; AG and TFMA were supported by the Munich Cluster for Systems Neurology (SyNergy). AG was supported by Fondazione Umberto Veronesi. SP is a Royal Society University Research fellow. BMM, CF, BSP and SEF are supported by the Max Planck Society. AW, BM and HK were funded by the Fraunhofer Society and the Max Planck Society within the 'Pakt für Forschung und Innovation'. HK was also supported by LIFE—Leipzig Research Center for Civilization Diseases funded by means of the European Union ; the European Regional Development Fund (ERDF) ; and the Free State of Saxony within the excellence initiative. FR is supported by Agence Nationale de la Recherche (ANR-06-NEURO-019-01, ANR-17-EURE-0017 IEC, ANR-10-IDEX-0001-02 PSL, ANR-11-BSV4-014-01), European Commission (LSHM-CT-2005-018696). TFMA was supported by the B.M.B.F. through the DIFUTURE consortium of the Medical Informatics Initiative Germany (grant 01ZZ1804A) and by the European Union’s Horizon 2020 Research and Innovation Programme (grant MultipleMS, EU RIA 733161). ; ANR-06-NEUR-0019,GENEDYS,Origines cognitives, neurologiques et génétiques des troubles développementaux du langage(2006) ; ANR-17-EURE-0017,FrontCog,Frontières en cognition(2017) ; ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010) ; ANR-11-BSV4-0014,DYSBRAIN,Le cerveau dyslexique(2011) ; Graz University of Technology [Graz] (TU Graz)-Medical University Graz-Karl-Franzens-Universität [Grazriche] ; Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II ; Helmholtz Zentrum München = German Research Center for Environmental Health ; Universität Bonn = University of Bonn ; Radboud University [Nijmegen] ; Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI) ; Université Toulouse - Jean Jaurès (UT2J) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J) ; Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT) ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) ; Université de Lausanne = University of Lausanne (UNIL) ; University of Oxford ; Universität Heidelberg [Heidelberg] = Heidelberg University ; Leipzig, Universität ; École normale supérieure - Paris (ENS-PSL) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL) ; Graz University of Technology [Graz] (TU Graz)-Karl-Franzens-Universität Graz-Medical University Graz ; Helsingin yliopisto = Helsingfors universitet = University of Helsinki ; The Royal Society ; University of St Andrews. School of Medicine ; University of St Andrews. Centre for Biophotonics ; University of St Andrews. Biomedical Sciences Research Complex ; University of St Andrews. Cellular Medicine Division |
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| Quelle: | Mol. Psychiatry 26, 3004–3017 (2021) Molecular Psychiatry Molecular Psychiatry, 26, pp. 3004-3017 Molecular Psychiatry, 26(7), 3004-3017. Nature Publishing Group Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ Molecular Psychiatry, 2020, ⟨10.1038/s41380-020-00898-x⟩ Molecular psychiatry, vol. 26, no. 7, pp. 3004-3017 Molecular Psychiatry, 26, 3004-3017 |
| Veröffentlichung: | Springernature, 2021 |
| Medientyp: | unknown |
| ISSN: | 2005-0186 (print) ; 1359-4184 (print) ; 1476-5578 (print) |
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