Serum Creatinine, Cystatin C, and -Trace Protein in Diagnostic Staging and Predicting Progression of Primary Nondiabetic Chronic Kidney Disease
In: Clinical Chemistry, Jg. 56 (2010-03-11), S. 740-749
Online
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Zugriff:
Background: Impaired baseline kidney function is a well-defined risk factor for progression of chronic kidney disease (CKD). We evaluated measured glomerular filtration rate (GFR) and the serum markers creatinine, cystatin C, and β-trace protein (BTP) for diagnostic accuracy in defining the stage of kidney impairment and as risk predictors of CKD progression. Methods: We measured serum marker concentrations in 227 patients with primary nondiabetic CKD and various degrees of renal impairment and followed 177 patients prospectively for up to 7 years to assess progression of CKD. Results: At baseline, creatinine, cystatin C, and BTP were strongly correlated with GFR as measured by iohexol clearance. Concentrations of all 3 markers increased progressively with decreasing GFR, and their diagnostic performance for the detection of even minor deteriorations of renal function (GFR
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Serum Creatinine, Cystatin C, and -Trace Protein in Diagnostic Staging and Predicting Progression of Primary Nondiabetic Chronic Kidney Disease
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Autor/in / Beteiligte Person: | Katharina-Susanne, Spanaus ; Barbara, Kollerits ; Eberhard, Ritz ; Martin, Hersberger ; Florian, Kronenberg ; Arnold, von Eckardstein ; Peter, Riegler |
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Zeitschrift: | Clinical Chemistry, Jg. 56 (2010-03-11), S. 740-749 |
Veröffentlichung: | Oxford University Press (OUP), 2010 |
Medientyp: | unknown |
ISSN: | 1530-8561 (print) ; 0009-9147 (print) |
DOI: | 10.1373/clinchem.2009.138826 |
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