Atypical functional connectivity in adolescents and adults with persistent and remitted ADHD
Cold Spring Harbor Laboratory, 2017
Online
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Zugriff:
We previously provided initial evidence for cognitive and event-related potential markers of persistence/remission of attention-deficit/hyperactivity disorder (ADHD) from childhood to adolescence and adulthood. In this follow-up study, using a novel brain-network connectivity approach, we aimed to examine whether functional connectivity reflects a marker of ADHD remission, or an enduring deficit unrelated to ADHD outcome. High-density EEG was recorded in 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 typically-developing individuals during an arrow-flanker task, eliciting cognitive control. Functional connectivity was quantified with network-based graph-theory metrics before target onset (pre-stimulus), during target processing (post-stimulus) and in the degree of change between pre-stimulus/post-stimulus. ADHD outcome was examined with parent-reported symptoms and impairment using both a categorical (DSM-IV) and a dimensional approach. Graph-theory measures converged in indicating that, compared to controls, ADHD persisters showed increased connectivity in pre-stimulus theta, alpha and beta and in post-stimulus beta (all p
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Atypical functional connectivity in adolescents and adults with persistent and remitted ADHD
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Autor/in / Beteiligte Person: | Jurgiel, Joseph ; Loo, Sandra K. ; Michelini, Giorgia ; Asherson, Philip ; Chm, Cheung ; Mohammad-Rezazadeh, Iman ; Kuntsi, Jonna ; Bakolis, Ioannis |
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Veröffentlichung: | Cold Spring Harbor Laboratory, 2017 |
Medientyp: | unknown |
DOI: | 10.1101/201772 |
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