MMP-9 microsatellite polymorphism and susceptibility to exudative form of age-related macular degeneration
In: Genetics in Medicine, Jg. 7 (2005-04-01), S. 272-277
Online
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Zugriff:
Purpose: To assess if a polymorphism (PM) of the microsatellite (CA13–27) in the promoter region of Matrix Metalloproteinase 9 (MMP-9) was associated with the exudative form of age-related macular degeneration (AMD) and to its risk factors. Methods: In 107 patients with AMD (AMD Group) and 223 age- and gender-matched controls (Control Group) with cataract, demographic, clinical data, and MMP-9 PM have been compared. Results: The comparison of allelic frequencies showed a different pattern of CA repeats between AMD and Control Group (P < 0.00005), in particular the prevalence of longer microsatellites (≥ 22 CA repeats) was higher in AMD than in Control Group (O.R. 2.49, 95% CI 1.71 - 3.37, P < 0.001). Analyses of genetic frequencies gave similar results. Logistic regression confirmed that 22 or more CA repeats are associated to AMD. The only association between MMP-9 PM and other risk factors for AMD was with BMI (Spearman’s R = 0.298, P < 0.00005): all patients with both microsatellites ≥ 22 CA repeats were overweight or obese (χ2 test P < 0.0005, compared to other genotypes). Conclusions: Longer microsatellites in the promoter of MMP-9 are associated to the exudative form of AMD and to body mass index, a well-known risk factor for the disease.
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MMP-9 microsatellite polymorphism and susceptibility to exudative form of age-related macular degeneration
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Autor/in / Beteiligte Person: | Fiotti, Nicola ; Giansante, Carlo ; Altamura, Nicola ; Uxa, Laura ; Maurizio Battaglia Parodi ; Pedio, Marcella ; Ravalico, Giuseppe ; Guarnieri, Gianfranco ; Pedio, M ; BATTAGLIA PARODI, M ; Altamura, N ; Uxa, L |
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Zeitschrift: | Genetics in Medicine, Jg. 7 (2005-04-01), S. 272-277 |
Veröffentlichung: | Elsevier BV, 2005 |
Medientyp: | unknown |
ISSN: | 1098-3600 (print) |
DOI: | 10.1097/01.gim.0000159903.69597.73 |
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