Larger than Dbl: new structural insights into RhoA activation
In: Trends in Biochemical Sciences, Jg. 30 (2005-04-01), S. 163-165
Online
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Zugriff:
Dbl homology (DH) domains are almost always followed immediately by pleckstrin homology (PH) domains in Dbl family proteins, and these DH-PH fragments directly activate GDP-bound Rho GTPases by catalyzing the exchange of GDP for GTP. New crystal structures of the DH-PH domains from leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) and PDZ-RhoGEF bound to RhoA reveal how DH-PH domains cooperate to specifically activate Rho GTPases.
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Larger than Dbl: new structural insights into RhoA activation
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Autor/in / Beteiligte Person: | Rossman, Kent L. ; Sondek, John |
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Zeitschrift: | Trends in Biochemical Sciences, Jg. 30 (2005-04-01), S. 163-165 |
Veröffentlichung: | Elsevier BV, 2005 |
Medientyp: | unknown |
ISSN: | 0968-0004 (print) |
DOI: | 10.1016/j.tibs.2005.02.002 |
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