A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs
In: Life Sciences, Jg. 60 (1997-05-01), S. PL345- (7S.)
Online
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Zugriff:
A multiple screening approach to detect compounds inhibitory to various aspects of the human immunodeficiency virus type 1 (HIV-1) life-cycle has been applied to aqueous extracts of 19 herbs traditionally used in Chinese medicine as anti-viral agents. The extracts were tested for their ability to inhibit HIV-1 in a series of in vitro assays. The extracts were tested for inhibition of the interaction between HIV-1 gp120 and immobilized CD4 receptor, inhibition of recombinant HIV-1 reverse transcriptase and for inhibition of three glycohydrolase enzymes that contribute to viral protein glycosylation. Six of the herb extracts (30%) were potent inhibitors of the interaction between HIV-1 gp120 and the CD4 receptor (ID50 5.6 - 79.4 microg/ml), two extracts (10%) contained potent reverse transcriptase inhibitors (ID50 16.9 - 26.0 microg/ml) and 14 extracts (75%) were able to inhibit at least one of the glycohydrolase enzymes.
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A comparison of human immunodeficiency virus type 1 inhibition by partially purified aqueous extracts of chinese medicinal herbs
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Autor/in / Beteiligte Person: | Collins, Richard A. ; Yeung, H.W. ; Fong, Wing-Ping ; Wan, C.C. ; Tzi Bun Ng |
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Zeitschrift: | Life Sciences, Jg. 60 (1997-05-01), S. PL345- (7S.) |
Veröffentlichung: | Elsevier BV, 1997 |
Medientyp: | unknown |
ISSN: | 0024-3205 (print) |
DOI: | 10.1016/s0024-3205(97)00227-0 |
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