Diagnostic performance of chest computed tomography during the epidemic wave of COVID-19 varied as a function of time since the beginning of the confinement in France

Lucidarme, Olivier ; Renard-Penna, Raphaële ; et al.

In: PLOS ONE, Jg. 15 (2020-11-23), Heft 11, p e0242840, S. e0242840

Online unknown

Zugriff:

Objective To evaluate the diagnostic performance of the initial chest CT to diagnose COVID-19 related pneumonia in a French population of patients with respiratory symptoms according to the time from the onset of country-wide confinement to better understand what could be the role of the chest CT in the different phases of the epidemic. Material and method Initial chest CT of 1064 patients with respiratory symptoms suspect of COVID-19 referred between March 18th, and May 12th 2020, were read according to a standardized procedure. The results of chest CTs were compared to the results of the RT-PCR. Results 546 (51%) patients were found to be positive for SARS-CoV2 at RT-PCR. The highest rate of positive RT-PCR was during the second week of confinement reaching 71.9%. After six weeks of confinement, the positive RT-PCR rate dropped significantly to 10.5% (p Conclusion At the peak of the epidemic, chest CT had sufficiently high sensitivity and PPV to serve as a first-line positive diagnostic tool but at the end of the epidemic wave CT is more useful to exclude COVID-19 pneumonia.

Titel:	Diagnostic performance of chest computed tomography during the epidemic wave of COVID-19 varied as a function of time since the beginning of the confinement in France
Autor/in / Beteiligte Person:	Lucidarme, Olivier ; Renard-Penna, Raphaële ; Salem, Joe-Elie ; Wagner, Mathilde ; Boussouar, Samia ; Donciu, Victoria ; Redheuil, Alban ; Marot, Stéphane ; Pasi, Nicoletta ; Freund, Yonathan ; Laboratoire d'Imagerie Biomédicale (LIB) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU) ; Sorbonne Université - Faculté de Médecine (SU FM) ; Sorbonne Université (SU) ; Service de pharmacologie médicale [CHU Pitié-Salpêtrière] ; CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) ; Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Service des Urgences [CHU Pitié-Salpêtrière] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP]
Link:	View record in OpenAIRE (Volltext) https://doi.org/10.1371/journal.pone.0242840
Zeitschrift:	PLOS ONE, Jg. 15 (2020-11-23), Heft 11, p e0242840, S. e0242840
Veröffentlichung:	Public Library of Science (PLoS), 2020
Medientyp:	unknown
ISSN:	1932-6203 (print)
DOI:	10.1371/journal.pone.0242840
Schlagwort:	Male Viral Diseases Pulmonology Epidemiology COVID19 [SDV]Life Sciences [q-bio] Chest ct Artificial Gene Amplification and Extension Computed tomography 030204 cardiovascular system & hematology Polymerase Chain Reaction [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Diagnostic Radiology 030218 nuclear medicine & medical imaging Medical Conditions 0302 clinical medicine Medicine and Health Sciences Tomography Virus Testing Aged, 80 and over education.field_of_study Multidisciplinary medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction Radiology and Imaging Middle Aged Reference Standards Prognosis Pulmonary Imaging 3. Good health Infectious Diseases Medicine Female France Radiology Research Article Adult medicine.medical_specialty 2019-20 coronavirus outbreak Adolescent Coronavirus disease 2019 (COVID-19) Imaging Techniques Science Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Population Neuroimaging Research and Analysis Methods Sensitivity and Specificity Infectious Disease Epidemiology Young Adult 03 medical and health sciences Computed Tomography Diagnostic Medicine medicine Humans Molecular Biology Techniques education Molecular Biology Pandemics Aged Retrospective Studies SARS-CoV-2 business.industry Biology and Life Sciences COVID-19 Covid 19 Reverse Transcriptase-Polymerase Chain Reaction Pneumonia medicine.disease Mass Chest X-Ray Computed Axial Tomography Pulmonary imaging Tomography, X-Ray Computed business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Neuroscience
Sonstiges:	Nachgewiesen in: OpenAIRE Rights: OPEN

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