Is Hyperopia an Important Risk Factor for PACG in the Dutch Population?—A Case Control Study

Objectives. To determine if hyperopia is a risk factor for primary angle-closure glaucoma (PACG) in the Dutch population and to identify other biometrical parameters as risk factors for PACG including axial length (AL), anterior chamber depth (ACD), andkvalues.Methods. The study population consisted of PACG patients that had undergone a laser peripheral iridotomy (LPI). The control group consisted of age- and gender-matched cataract patients. The main outcome was hyperopia (spherical equivalent ≥+0.5 dioptres) measured with IOL Master or autorefractor. Refractive error, ACD, AL, andkvalues were tested with a Mann-WhitneyUtest and by logistic regression.Results. 117 PACG patients and 234 controls were included (mean age = 80 years ± 3.6). The prevalence of hyperopia in patients and controls was 69.6% and 61.1%, respectively (Fisher’s testP=0.076). Mann-WhitneyUtest showed no statistically significant relation with refractive error (P=0.068) orkvalues (P=0.607). In contrast, ACD and AL were statistically significant (P<0.001). Tested with logistic regression, only ACD was a significant predictor of PACG (P<0.001).Conclusion. There was no statistically significant correlation between refractive error and PACG. ACD was strongly correlated, though, with PACG, whereas AL turned out to be a less significant risk factor.