Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans
In: Journal of Clinical Periodontology, Jg. 48 (2021-11-01), Heft 11, S. 1404-1413
Online
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Zugriff:
© 2021 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.Aims: Various studies have reported that young European women are more likely to develop early-onset periodontitis compared to men. A potential explanation for the observed variations in sex and age of disease onset is the natural genetic variation within the autosomal genomes. We hypothesized that genotype-by-sex (G × S) interactions contribute to the increased prevalence and severity. Materials and methods: Using the case-only design, we tested for differences in genetic effects between men and women in 896 North-West European early-onset cases, using imputed genotypes from the OmniExpress genotyping array. Population-representative 6823 controls were used to verify that the interacting variables G and S were uncorrelated in the general population. Results: In total, 20 loci indicated G × S associations (P < 0.0005), 3 of which were previously suggested as risk genes for periodontitis (ABLIM2, CDH13, and NELL1). We also found independent G × S interactions of the related gene paralogs MACROD1/FLRT1 (chr11) and MACROD2/FLRT3 (chr20). G × S-associated SNPs at CPEB4, CDH13, MACROD1, and MECOM were genome-wide-associated with heel bone mineral density (CPEB4, MECOM), waist-to-hip ratio (CPEB4, MACROD1), and blood pressure (CPEB4, CDH13). Conclusions: Our results indicate that natural genetic variation affects the different heritability of periodontitis among sexes and suggest genes that contribute to inter-sex phenotypic variation in early-onset periodontitis.
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Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans
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Autor/in / Beteiligte Person: | Graetz, Christian ; Loos, Bruno G. ; Bruckmann, Corinna ; Jockel-Schneider, Yvonne ; Franke, Andre ; Staufenbiel, Ingmar ; Freitag-Wolf, Sandra ; Schaefer, Arne S. ; Junge, Olaf ; Munz, Matthias ; Jepsen, Søren ; Dommisch, Henrik ; Lieb, Wolfgang ; Periodontology |
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Zeitschrift: | Journal of Clinical Periodontology, Jg. 48 (2021-11-01), Heft 11, S. 1404-1413 |
Veröffentlichung: | 2021 |
Medientyp: | unknown |
ISSN: | 0303-6979 (print) |
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