The role of cognitive functioning in the relationship between childhood trauma and a mixed phenotype of affective-anxious-psychotic symptoms in psychotic disorders
In: Schizophrenia Research, Jg. 192 (2018-02-01), S. 262-268
Online
unknown
Zugriff:
Cognitive impairments in patients with psychotic disorder have been associated with poor functioning and increased symptom severity. Furthermore, childhood trauma (CT) exposure has been associated with worse cognitive functioning as well as co-occurrence of affective-anxious-psychosis symptoms or a 'mixed phenotype of psychopathology' (MP), which in turn is associated with greater symptom severity, and poor functioning. This study aims to evaluate if cognition could be associated with CT/MP.& para;& para;532 patients with non-affective psychotic patients were assessed on Cl', symptom profile, cognition, functioning, and symptom severity at baseline and 3 and 6-year follow-up. Four subgroups were made according to trauma exposure (CT- or CT+) and presence of a mixed phenotype (MP- or MP +-): CT-/MP (n = 272), CT-I MP+ (n = 157), CT-IMP- (n = 49), and CT+/MP + (n = 54). Mixed-effects multilevel regression, linear regression, and Tobit analyses were performed.& para;& para;Patients with both CT and MP showed lower verbal learning and memory than CT-/MP+ individuals (p
| Titel: |
The role of cognitive functioning in the relationship between childhood trauma and a mixed phenotype of affective-anxious-psychotic symptoms in psychotic disorders
|
|---|---|
| Autor/in / Beteiligte Person: | Jim van Os ; Schirmbeck, Frederike ; Kahn, René S. ; Cahn, Wiepke ; Delespaul, Philippe ; Simons, Claudia J. P. ; Neeltje E.M. van Haren ; Meijer, Carin J. ; Schruers, Koen ; Alizadeh, Berhooz Z. ; Martine van Nierop ; Nico J.M. van Beveren ; Bartels-Velthuis, Agna A. ; Ruud van Winkel ; Lieuwe de Haan ; Bruggeman, Richard ; Mansueto, Giovanni ; Myin-Germeys, Inez ; Neurosciences ; Psychiatry ; Child and Adolescent Psychiatry / Psychology ; RS: MHeNs - R2 - Mental Health ; Psychiatrie & Neuropsychologie ; MUMC+: MA Psychiatrie (3) ; MUMC+: Hersen en Zenuw Centrum (3) ; APH - Mental Health ; ANS - Mood, Anxiety, Psychosis, Stress & Sleep ; Psychiatry, Adult ; departments, Other ; Perceptual and Cognitive Neuroscience (PCN) ; Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| Link: | |
| Zeitschrift: | Schizophrenia Research, Jg. 192 (2018-02-01), S. 262-268 |
| Veröffentlichung: | Elsevier BV, 2018 |
| Medientyp: | unknown |
| ISSN: | 0920-9964 (print) |
| DOI: | 10.1016/j.schres.2017.04.003 |
| Schlagwort: |
|
| Sonstiges: |
|